/* =========================================================
   BIONiRS / MamoRef — hoja de estilos compartida
   Editá estas variables para ajustar el look & feel global.
   ========================================================= */

/* ---------- fuentes (self-hosted, sin dependencia de Google Fonts) ---------- */
@font-face{
  font-family:'Lato';font-style:normal;font-weight:400;font-display:swap;
  src:url('/assets/fonts/lato-400.woff2') format('woff2');
}
@font-face{
  font-family:'Lato';font-style:italic;font-weight:400;font-display:swap;
  src:url('/assets/fonts/lato-400-italic.woff2') format('woff2');
}
@font-face{
  font-family:'Lato';font-style:normal;font-weight:700;font-display:swap;
  src:url('/assets/fonts/lato-700.woff2') format('woff2');
}
@font-face{
  font-family:'Lato';font-style:normal;font-weight:900;font-display:swap;
  src:url('/assets/fonts/lato-900.woff2') format('woff2');
}
@font-face{
  font-family:'Encode Sans';font-style:normal;font-weight:400 600;font-display:swap;
  src:url('/assets/fonts/encode-sans-variable.woff2') format('woff2');
}
@font-face{
  font-family:'Quicksand';font-style:normal;font-weight:500 700;font-display:swap;
  src:url('/assets/fonts/quicksand-variable.woff2') format('woff2');
}

:root{
  /* Marca (Manual de Identidad Corporativa BIONiRS) */
  --blue-900:#003a6b;
  --blue-800:#004580; /* azul principal Pantone 2154C */
  --blue-700:#0b5aa0;
  --blue-500:#0085c8;
  --blue-100:#e6eef6;
  --blue-050:#f3f7fb;

  --orange-600:#d43f17;
  --orange-500:#e94b26; /* naranja principal Pantone 172C */
  --orange-100:#fde9e2;

  --ink:#1c2630;
  --slate:#485663;
  --slate-light:#7c8a97;
  --line:#e2e8ee;
  --paper:#ffffff;
  --cream:#fbfaf7;

  --font-display:'Quicksand', sans-serif;
  --font-head:'Lato', sans-serif;
  --font-body:'Encode Sans', sans-serif;

  --container:1180px;
  --radius:14px;
  --radius-sm:8px;
  --shadow:0 10px 30px -14px rgba(0,58,107,0.25);
  --shadow-sm:0 4px 14px -8px rgba(0,58,107,0.25);
}

*,*::before,*::after{box-sizing:border-box;}
html{scroll-behavior:smooth;color-scheme:light;}
[id]{scroll-margin-top:96px;}
:focus-visible{outline:3px solid var(--orange-500);outline-offset:2px;border-radius:4px;}
.skip-link{
  position:absolute;left:12px;top:-60px;z-index:100;
  background:var(--orange-500);color:#fff;
  font-family:var(--font-head);font-weight:700;font-size:.9rem;
  padding:10px 18px;border-radius:var(--radius-sm);
  text-decoration:none;
  transition:top .15s ease;
}
.skip-link:focus{top:12px;}
@media (prefers-reduced-motion:reduce){
  html{scroll-behavior:auto;}
  *,*::before,*::after{transition-duration:.001ms!important;animation-duration:.001ms!important;}
}
body{
  margin:0;
  font-family:var(--font-body);
  color:var(--ink);
  background:var(--paper);
  line-height:1.6;
  -webkit-font-smoothing:antialiased;
}
img{max-width:100%;height:auto;display:block;}
a{color:inherit;}
h1,h2,h3,h4{
  font-family:var(--font-display);
  font-weight:700;
  line-height:1.15;
  margin:0 0 .5em;
  color:var(--blue-900);
}
p{margin:0 0 1em;}
.container{
  width:100%;
  max-width:var(--container);
  margin:0 auto;
  padding:0 24px;
}
section{padding:88px 0;}
.section-tight{padding:56px 0;}
.bg-tint{background:var(--blue-050);}
.bg-cream{background:var(--cream);}
.bg-dark{background:var(--blue-900);color:#dce8f3;}
.bg-dark h2,.bg-dark h3{color:#fff;}

.eyebrow{
  display:inline-flex;
  align-items:center;
  gap:8px;
  font-family:var(--font-head);
  font-weight:700;
  letter-spacing:.08em;
  text-transform:uppercase;
  font-size:.78rem;
  color:var(--orange-600);
  margin-bottom:14px;
}
.eyebrow::before{
  content:"";
  width:22px;height:2px;
  background:var(--orange-500);
  display:inline-block;
}
.bg-dark .eyebrow{color:#ff9d75;}
.bg-dark .eyebrow::before{background:#ff9d75;}

h2{font-size:clamp(1.7rem,3vw,2.3rem);}
h3{font-size:1.25rem;}
.lede{
  font-size:1.1rem;
  color:var(--slate);
  max-width:60ch;
}
.bg-dark .lede{color:#b9cde0;}

/* ---------- buttons ---------- */
.btn{
  display:inline-flex;
  align-items:center;
  gap:8px;
  font-family:var(--font-head);
  font-weight:700;
  font-size:.95rem;
  padding:13px 24px;
  border-radius:999px;
  text-decoration:none;
  border:2px solid transparent;
  cursor:pointer;
  transition:transform .15s ease, box-shadow .15s ease, background .15s ease, color .15s ease;
}
.btn:hover{transform:translateY(-2px);}
.btn-primary{
  background:var(--orange-500);
  color:#fff;
  box-shadow:0 10px 24px -10px rgba(233,75,38,.55);
}
.btn-primary:hover{background:var(--orange-600);}
.btn-outline{
  background:transparent;
  border-color:rgba(255,255,255,.55);
  color:inherit;
}
.btn-outline:hover{background:rgba(255,255,255,.12);}
.btn-ghost-blue{
  background:transparent;
  border-color:var(--blue-800);
  color:var(--blue-800);
}
.btn-ghost-blue:hover{background:var(--blue-800);color:#fff;}
.btn-sm{padding:9px 18px;font-size:.85rem;}
.btn-row{display:flex;flex-wrap:wrap;gap:14px;margin-top:28px;}

/* ---------- header ---------- */
.site-header{
  position:sticky;top:0;z-index:50;
  background:rgba(255,255,255,.92);
  backdrop-filter:blur(8px);
  border-bottom:1px solid var(--line);
}
.site-header .container{
  display:flex;align-items:center;justify-content:space-between;
  height:78px;
}
.brand{display:flex;align-items:center;gap:10px;text-decoration:none;}
.brand img{height:40px;width:auto;}
.main-nav{display:flex;align-items:center;gap:6px;}
.main-nav a{
  font-family:var(--font-head);
  font-weight:700;
  font-size:.92rem;
  color:var(--blue-900);
  text-decoration:none;
  padding:10px 14px;
  border-radius:999px;
  transition:background .15s ease, color .15s ease;
}
.main-nav a:hover,.main-nav a.active{background:var(--blue-100);}
.nav-cluster{display:flex;align-items:center;gap:18px;}
.lang-switch{
  display:flex;gap:4px;
  font-family:var(--font-head);font-weight:700;font-size:.82rem;
  border:1px solid var(--line);
  border-radius:999px;padding:3px;
  background:var(--blue-050);
}
.lang-switch a{
  padding:6px 12px;border-radius:999px;text-decoration:none;color:var(--slate);
}
.lang-switch a.current{background:var(--blue-800);color:#fff;}
.nav-toggle{
  display:none;
  background:none;border:none;cursor:pointer;
  width:42px;height:42px;border-radius:10px;
  align-items:center;justify-content:center;
}
.nav-toggle span,.nav-toggle span::before,.nav-toggle span::after{
  content:"";display:block;width:22px;height:2px;background:var(--blue-900);
  position:relative;transition:transform .2s ease, opacity .2s ease;
}
.nav-toggle span::before{position:absolute;top:-7px;}
.nav-toggle span::after{position:absolute;top:7px;}

/* ---------- hero ---------- */
.hero{
  position:relative;
  overflow:hidden;
  background:linear-gradient(135deg,var(--blue-900) 0%,var(--blue-800) 55%,var(--blue-700) 100%);
  color:#fff;
  padding:72px 0 0;
}
.hero .container{
  display:grid;
  grid-template-columns:1.05fr .95fr;
  gap:48px;
  align-items:center;
}
.hero-copy .status-pill{
  display:inline-flex;align-items:center;gap:8px;
  background:rgba(255,255,255,.12);
  border:1px solid rgba(255,255,255,.25);
  padding:7px 14px;border-radius:999px;
  font-family:var(--font-head);font-weight:700;font-size:.78rem;
  letter-spacing:.03em;
  margin-bottom:22px;
}
.status-pill .dot{width:8px;height:8px;border-radius:50%;background:#5be28a;box-shadow:0 0 0 3px rgba(91,226,138,.25);}
.hero h1{
  color:#fff;
  font-size:clamp(2.1rem,4.2vw,3.1rem);
  margin-bottom:.4em;
}
.hero h1 em{color:#ffb088;font-style:normal;}
.hero .lede{color:#cfe0ef;max-width:52ch;font-size:1.12rem;}
.hero-figure{
  position:relative;
  border-radius:20px;
  overflow:hidden;
  box-shadow:0 30px 60px -20px rgba(0,0,0,.45);
  justify-self:end;
}
.hero-figure img{
  width:100%;height:100%;object-fit:cover;
  aspect-ratio:4/3;
}
.hero-figure figcaption{
  position:absolute;left:0;right:0;bottom:0;
  background:linear-gradient(0deg,rgba(0,20,40,.85),transparent);
  color:#fff;padding:18px 20px 14px;
  font-size:.82rem;font-family:var(--font-head);font-weight:600;
}
.hero-stats{
  margin-top:48px;
  border-top:1px solid rgba(255,255,255,.18);
  display:grid;grid-template-columns:repeat(4,1fr);
}
.hero-stats div{padding:22px 24px;border-right:1px solid rgba(255,255,255,.18);}
.hero-stats div:last-child{border-right:none;}
.hero-stats strong{
  display:block;font-family:var(--font-display);font-size:1.7rem;color:#fff;
}
.hero-stats span{font-size:.82rem;color:#b9cde0;}

/* ---------- 404 ---------- */
.error-hero{min-height:56vh;display:flex;align-items:center;padding:96px 0;}
.error-hero .container{display:block;text-align:center;}
.error-hero .eyebrow{justify-content:center;}
.error-hero .lede{margin:0 auto 8px;}
.error-hero .btn-row{justify-content:center;}

/* ---------- hex motif ---------- */
.hex-deco{
  position:absolute;
  width:420px;height:420px;
  background:var(--orange-500);
  opacity:.08;
  clip-path:polygon(25% 2%,75% 2%,100% 50%,75% 98%,25% 98%,0% 50%);
  pointer-events:none;
}

/* ---------- problem cards ---------- */
.stat-grid{
  display:grid;
  grid-template-columns:repeat(3,1fr);
  gap:22px;
  margin-top:40px;
}
.stat-card{
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:28px 24px;
  box-shadow:var(--shadow-sm);
}
.stat-card .big{
  font-family:var(--font-display);
  font-size:2.4rem;
  color:var(--orange-500);
  display:block;
  margin-bottom:6px;
}
.stat-card p{color:var(--slate);margin:0;font-size:.95rem;}

/* ---------- two column ---------- */
.split{
  display:grid;
  grid-template-columns:1fr 1fr;
  gap:56px;
  align-items:center;
}
.split.reverse .split-media{order:2;}
.split-media img{border-radius:var(--radius);box-shadow:var(--shadow);}
.media-card{
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:20px;
  box-shadow:var(--shadow-sm);
}
.media-card img{border-radius:8px;}
.media-card img.zoomable{cursor:zoom-in;transition:opacity .15s ease;}
.media-card img.zoomable:hover{opacity:.88;}
.media-caption{font-size:.85rem;color:var(--slate-light);margin-top:12px;margin-bottom:0;}

/* ---------- advantages grid ---------- */
.adv-grid{
  display:grid;
  grid-template-columns:repeat(3,1fr);
  gap:20px;
  margin-top:40px;
}
.adv-card{
  display:flex;gap:16px;align-items:flex-start;
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:22px;
}
.adv-icon{
  flex:none;width:46px;height:46px;border-radius:12px;
  background:var(--blue-100);color:var(--blue-800);
  display:flex;align-items:center;justify-content:center;
}
.adv-icon svg{width:24px;height:24px;}
.adv-card h3{font-size:1rem;margin-bottom:4px;}
.adv-card p{font-size:.9rem;color:var(--slate);margin:0;}

/* ---------- roadmap / hitos ---------- */
.roadmap{
  display:grid;
  grid-template-columns:1fr 1fr;
  gap:28px;
  margin-top:40px;
}
.roadmap-col{
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:30px 28px;
}
.roadmap-col.done{border-top:4px solid var(--blue-800);}
.roadmap-col.next{border-top:4px solid var(--orange-500);}
.roadmap-col h3{display:flex;align-items:center;gap:10px;}
.roadmap-col ul{list-style:none;margin:18px 0 0;padding:0;display:flex;flex-direction:column;gap:14px;}
.roadmap-col li{
  font-size:.95rem;color:var(--slate);
}
.roadmap-col li svg{float:left;width:20px;height:20px;margin:2px 12px 0 0;}
.roadmap-col.done li svg{color:var(--blue-800);}
.roadmap-col.next li svg{color:var(--orange-500);}

/* ---------- publications ---------- */
.pub-list{display:flex;flex-direction:column;gap:16px;margin-top:36px;}
.pub-card{
  display:grid;
  grid-template-columns:auto 1fr auto;
  gap:20px;align-items:center;
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:22px 24px;
  box-shadow:var(--shadow-sm);
}
.pub-tag{
  font-family:var(--font-head);font-weight:700;font-size:.72rem;
  letter-spacing:.05em;text-transform:uppercase;
  color:var(--blue-800);background:var(--blue-100);
  padding:6px 12px;border-radius:999px;white-space:nowrap;
}
.pub-card h3{font-size:1.02rem;margin-bottom:4px;}
.pub-card p{font-size:.86rem;color:var(--slate-light);margin:0;}

/* ---------- case cards ---------- */
.case-grid{display:grid;grid-template-columns:1fr 1fr;gap:22px;margin-top:40px;}
.case-card{
  border-radius:var(--radius);
  padding:26px;
  border:1px solid var(--line);
  background:var(--paper);
}
.case-card.malign{border-top:4px solid var(--orange-500);}
.case-card.benign{border-top:4px solid var(--blue-800);}
.case-card ul{margin:14px 0 0;padding-left:1.1em;color:var(--slate);font-size:.92rem;}
.case-card li{margin-bottom:6px;}

/* ---------- people / team roster ---------- */
.people-grid{
  display:grid;
  grid-template-columns:repeat(3,1fr);
  gap:18px;
  margin-top:32px;
}
.person-card{
  display:flex;gap:14px;align-items:flex-start;
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:18px 20px;
}
.person-avatar{
  flex:none;width:56px;height:56px;border-radius:50%;
  background:var(--blue-100);color:var(--blue-800);
  display:flex;align-items:center;justify-content:center;
  font-family:var(--font-display);font-weight:700;font-size:1rem;
  overflow:hidden;
}
.person-avatar img{width:100%;height:100%;object-fit:cover;display:block;}
.person-card h4{margin:0 0 2px;font-family:var(--font-head);font-size:.95rem;color:var(--ink);}
.person-card span{font-size:.8rem;color:var(--slate-light);}
.person-card p{font-size:.82rem;color:var(--slate);margin:8px 0 0;line-height:1.5;}

/* ---------- social cards ---------- */
.social-grid{
  display:grid;
  grid-template-columns:repeat(4,1fr);
  gap:18px;
  margin-top:36px;
}
.social-card{
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:28px 20px;
  text-align:center;
}
.social-card .social-icon{
  width:52px;height:52px;border-radius:50%;
  background:var(--blue-100);color:var(--blue-800);
  display:flex;align-items:center;justify-content:center;
  margin:0 auto 16px;
}
.social-card .social-icon svg{width:22px;height:22px;}
.social-card h3{font-size:1rem;margin-bottom:2px;}
.social-card span{display:block;font-size:.85rem;color:var(--slate-light);margin-bottom:18px;}

/* ---------- faq ---------- */
.faq-list{max-width:880px;margin-top:36px;display:flex;flex-direction:column;gap:12px;}
.faq-item{
  background:var(--paper);
  border:1px solid var(--line);
  border-radius:var(--radius);
  padding:4px 22px;
}
.faq-item summary{
  padding:18px 0;
  font-family:var(--font-head);font-weight:700;font-size:1rem;
  color:var(--blue-900);
  cursor:pointer;
  list-style:none;
  display:flex;align-items:center;justify-content:space-between;gap:16px;
}
.faq-item summary::-webkit-details-marker{display:none;}
.faq-item summary::after{
  content:"+";
  flex:none;
  font-family:var(--font-display);font-size:1.3rem;color:var(--orange-500);
  transition:transform .15s ease;
}
.faq-item[open] summary::after{transform:rotate(45deg);}
.faq-item p{color:var(--slate);font-size:.95rem;margin:0 0 20px;}

/* ---------- callout ---------- */
.callout{
  background:var(--blue-050);
  border-left:4px solid var(--blue-800);
  border-radius:0 10px 10px 0;
  padding:18px 22px;
  margin:28px 0;
  font-size:.92rem;
  color:var(--slate);
}
.callout strong{color:var(--blue-900);}
.callout.warn{background:var(--orange-100);border-left-color:var(--orange-500);}

/* ---------- spec table ---------- */
.spec-table{width:100%;border-collapse:collapse;margin:20px 0;font-size:.92rem;}
.spec-table th,.spec-table td{text-align:left;padding:10px 14px;border-bottom:1px solid var(--line);}
.spec-table th{color:var(--slate-light);font-family:var(--font-head);font-weight:700;font-size:.78rem;text-transform:uppercase;letter-spacing:.04em;}
.spec-table td:first-child{color:var(--blue-900);font-weight:600;white-space:nowrap;}
.spec-table td{color:var(--slate);}

/* ---------- video embed ---------- */
.video-embed{
  position:relative;
  padding-top:56.25%;
  border-radius:var(--radius);
  overflow:hidden;
  box-shadow:var(--shadow);
  background:#000;
}
.video-embed iframe{
  position:absolute;inset:0;
  width:100%;height:100%;border:0;
}
.video-embed-play{
  position:absolute;inset:0;
  width:100%;height:100%;
  display:flex;flex-direction:column;align-items:center;justify-content:center;
  gap:14px;
  background:linear-gradient(135deg,var(--blue-900) 0%,var(--blue-800) 100%);
  border:0;cursor:pointer;color:#fff;
  font-family:var(--font-head);font-weight:700;font-size:1rem;
  transition:background .2s ease;
}
.video-embed-play:hover{background:linear-gradient(135deg,var(--blue-800) 0%,var(--blue-700) 100%);}
.video-embed-play .play-icon{
  width:64px;height:64px;border-radius:50%;
  background:var(--orange-500);color:#fff;
  display:flex;align-items:center;justify-content:center;
  box-shadow:0 10px 24px -8px rgba(233,75,38,.6);
  transition:transform .2s ease;
}
.video-embed-play:hover .play-icon{transform:scale(1.08);}

/* ---------- team / partners strip ---------- */
.partners-strip{
  display:flex;flex-wrap:wrap;gap:14px;margin-top:28px;
}
.partners-strip span{
  font-family:var(--font-head);font-weight:700;font-size:.85rem;
  border:1px solid var(--line);border-radius:999px;
  padding:9px 16px;color:var(--slate);background:var(--paper);
}

/* ---------- institutional logo strip ---------- */
.logo-strip{
  display:flex;flex-wrap:wrap;align-items:center;gap:18px;
  margin-top:28px;
}
.logo-strip img{
  height:56px;width:auto;display:block;
  background:#fff;border:1px solid var(--line);border-radius:var(--radius-sm);
  padding:12px 20px;
}

/* ---------- footer ---------- */
.site-footer{
  background:var(--blue-900);
  color:#b9cde0;
  padding:64px 0 28px;
}
.footer-grid{
  display:grid;
  grid-template-columns:1.3fr 1fr 1fr;
  gap:40px;
  padding-bottom:40px;
  border-bottom:1px solid rgba(255,255,255,.14);
}
.footer-brand img{height:36px;margin-bottom:16px;}
.footer-brand p{font-size:.9rem;max-width:36ch;color:#9fb6cb;}
.site-footer h4{
  color:#fff;font-family:var(--font-head);font-size:.82rem;
  text-transform:uppercase;letter-spacing:.06em;margin-bottom:16px;
}
.site-footer ul{list-style:none;margin:0;padding:0;display:flex;flex-direction:column;gap:10px;}
.site-footer a{text-decoration:none;color:#b9cde0;font-size:.92rem;}
.site-footer a:hover{color:#fff;}
.social-row{display:flex;gap:10px;margin-top:4px;}
.social-row a{
  width:36px;height:36px;border-radius:50%;
  border:1px solid rgba(255,255,255,.25);
  display:flex;align-items:center;justify-content:center;
}
.social-row a:hover{background:rgba(255,255,255,.12);}
.footer-bottom{
  display:flex;justify-content:space-between;flex-wrap:wrap;gap:10px;
  padding-top:24px;font-size:.8rem;color:#7f9ab3;
}

/* ---------- responsive ---------- */
@media (max-width:980px){
  .hero .container{grid-template-columns:1fr;}
  .hero-figure{justify-self:stretch;}
  .split{grid-template-columns:1fr;}
  .split .split-media{order:-1;}
  .stat-grid,.adv-grid,.people-grid,.social-grid{grid-template-columns:repeat(2,1fr);}
  .roadmap,.case-grid{grid-template-columns:1fr;}
  .footer-grid{grid-template-columns:1fr 1fr;}
}

/* ---------- lightbox ---------- */
.lightbox-overlay{
  position:fixed;inset:0;z-index:200;
  display:flex;align-items:center;justify-content:center;
  padding:40px;
  background:rgba(10,20,35,.92);
  opacity:0;visibility:hidden;
  transition:opacity .2s ease;
}
.lightbox-overlay.open{opacity:1;visibility:visible;}
.lightbox-img{
  max-width:100%;max-height:100%;
  border-radius:8px;
  box-shadow:0 20px 60px -10px rgba(0,0,0,.6);
  cursor:zoom-out;
}
.lightbox-close{
  position:absolute;top:18px;right:22px;
  width:44px;height:44px;border-radius:50%;
  background:rgba(255,255,255,.12);border:1px solid rgba(255,255,255,.3);
  color:#fff;font-size:1.6rem;line-height:1;
  display:flex;align-items:center;justify-content:center;
  cursor:pointer;
}
.lightbox-close:hover{background:rgba(255,255,255,.22);}
body.lightbox-locked{overflow:hidden;}

@media (max-width:760px){
  .main-nav{
    position:absolute;top:78px;left:0;right:0;
    background:#fff;border-bottom:1px solid var(--line);
    flex-direction:column;align-items:stretch;
    padding:12px;gap:2px;
    display:none;
    box-shadow:var(--shadow);
  }
  .main-nav.open{display:flex;}
  .main-nav a{padding:13px 16px;border-radius:10px;}
  .nav-toggle{display:flex;}
  .nav-cluster{gap:10px;}
  .hero-stats{grid-template-columns:repeat(2,1fr);}
  .hero-stats div:nth-child(2){border-right:none;}
  .stat-grid,.adv-grid,.footer-grid,.people-grid,.social-grid{grid-template-columns:1fr;}
  .pub-card{grid-template-columns:1fr;text-align:left;}
  section{padding:60px 0;}
}