{"id":16872,"date":"2021-08-03T19:32:21","date_gmt":"2021-08-03T19:32:21","guid":{"rendered":"http:\/\/bionirs.wwwaz1-lr4.supercp.com\/?page_id=16872"},"modified":"2024-08-29T20:17:29","modified_gmt":"2024-08-29T20:17:29","slug":"technology","status":"publish","type":"page","link":"https:\/\/bionirs.com\/index.php\/technology\/","title":{"rendered":"TECHNOLOGY"},"content":{"rendered":"[spb_row element_name=”Row” wrap_type=”content-width” parallax_image_height=”content-height” parallax_image_movement=”fixed” parallax_image_speed=”0.5″ bg_video_loop=”yes” parallax_video_height=”window-height” parallax_video_overlay=”none” row_overlay_opacity=”0″ row_col_pos=”default” minimize_row=”yes” width=”1\/1″ el_position=”first last”] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”1\/4″ el_position=”first”]\n

\"\"<\/p>\n[\/spb_text_block] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”3\/4″ el_position=”last”]\n

A decade of collaboration between Bionirs Arg SA and physicists from the Universidad Nacional del Centro de Buenos Aires (UNCPBA)<\/a> related to the propagation of light within biological tissues, specifically breast tissue, led to the development of an approach innovative and design of a clinical imaging device for the detection of breast cancer.<\/p>\n[\/spb_text_block] [\/spb_row] [spb_row element_name=”Row” wrap_type=”content-width” parallax_image_height=”content-height” parallax_image_movement=”fixed” parallax_image_speed=”0.5″ bg_video_loop=”yes” parallax_video_height=”window-height” parallax_video_overlay=”none” row_overlay_opacity=”0″ row_col_pos=”default” minimize_row=”yes” width=”1\/1″ el_position=”first last”] [spb_blank_spacer height=”30px” responsive_vis=”hidden-xs” width=”1\/1″ el_position=”first last”] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”1\/1″ el_position=”first last”]\n

\"\" How does MamoRef work?<\/h2>\n
MamoRef is based on the use of light in the near infrared (NIR) for the metabolic characterization of soft tissue and its operating principle is analogous to that of a pulse oximeter which uses the difference in light absorption between two wavelengths of wave in the near infrared to calculate the relative concentration of oxy and deoxyhemoglobin and, from them, the oxygen saturation.<\/span><\/div>\n[\/spb_text_block] [spb_blank_spacer height=”60px” width=”1\/1″ el_position=”first last”] [\/spb_row] [spb_row element_name=”Row” wrap_type=”content-width” parallax_image_height=”content-height” parallax_image_movement=”fixed” parallax_image_speed=”0.5″ bg_video_loop=”yes” parallax_video_height=”window-height” parallax_video_overlay=”none” row_overlay_opacity=”0″ row_col_pos=”default” minimize_row=”yes” width=”1\/1″ el_position=”first last”] [spb_column col_sm=”8″ padding_horizontal=”0″ width=”2\/3″ el_position=”first”] [spb_image title=”VERSI\u00d3N 2.0″ image=”17403″ image_size=”full” frame=”noframe” caption_pos=”hover” remove_rounded=”yes” fullwidth=”no” overflow_mode=”none” link_target=”_self” lightbox=”no” intro_animation=”none” animation_delay=”200″ width=”1\/1″ el_position=”first last”][\/spb_image] [spb_image title=”VERSI\u00d3N 1.1″ image=”16817″ image_size=”full” frame=”noframe” caption_pos=”hover” remove_rounded=”yes” fullwidth=”no” overflow_mode=”none” link_target=”_self” lightbox=”no” intro_animation=”none” animation_delay=”200″ width=”1\/1″ el_position=”first last”][\/spb_image] [\/spb_column] [spb_column col_sm=”4″ padding_horizontal=”0″ width=”1\/3″ el_position=”last”] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”1\/1″ el_position=”first last”]\n

MAmoRef consists of a station with a transparent window under which the measurement system is placed. The patient sits on a chair and lies with her breasts resting on the window, avoiding any compression, allowing any woman to use it without limitation.<\/p>\n

.<\/p>\n[\/spb_text_block] [spb_image image=”17414″ image_size=”full” frame=”noframe” caption_pos=”hover” remove_rounded=”yes” fullwidth=”no” overflow_mode=”none” link_target=”_self” lightbox=”no” intro_animation=”none” animation_delay=”200″ width=”1\/1″ el_position=”first last”][\/spb_image] [\/spb_column] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [\/spb_row] [spb_row element_name=”Row” wrap_type=”content-width” parallax_image_height=”content-height” parallax_image_movement=”fixed” parallax_image_speed=”0.5″ bg_video_loop=”yes” parallax_video_height=”window-height” parallax_video_overlay=”none” row_overlay_opacity=”0″ row_col_pos=”default” minimize_row=”yes” width=”1\/1″ el_position=”first last”] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”2\/3″ el_position=”first”]\n

About NIR light<\/h2>\n

This NIR light is between 600 and 900 nm in wavelength, in the so-called “optical or therapeutic window”<\/strong> (Figure 2)<\/em>, and is poorly absorbed by the most significant components of soft tissue, thus being able to penetrate them by several centimeters and explore them. When light enters the tissue, it does not travel a straight path but diffusely scatters or “scatters”, part of it leaving the same face that entered the tissue (that is, it is “diffusely” reflected). The way in which this propagation occurs as well as the amount of light that is absorbed at each wavelength depends on the physiological and metabolic characteristics of the tissue traversed.<\/span><\/p>\n

NIR light is known to provide valuable data on cell function and biological processes such as blood flow, hemoglobin concentration, and oxygen saturation. NIR imaging has been used to determine the concentration of oxygen saturation of hemoglobin in healthy and cancerous tissue.<\/span><\/h3>\n[\/spb_text_block] [spb_column col_sm=”4″ padding_horizontal=”0″ width=”1\/3″ el_position=”last”] [spb_image image=”16938″ image_size=”full” frame=”noframe” caption_pos=”hover” remove_rounded=”yes” fullwidth=”no” overflow_mode=”none” link_target=”_self” lightbox=”no” intro_animation=”none” animation_delay=”200″ width=”1\/1″ el_position=”first last”]\n

Figure 2: Taken from Vogel2003<\/span><\/em><\/p>\n[\/spb_image] [\/spb_column] [\/spb_row] [spb_row element_name=”Row” wrap_type=”full-width-contained” row_bg_type=”color” row_bg_color=”#355890″ color_row_height=”content-height” bg_type=”cover” parallax_image_height=”content-height” parallax_image_movement=”fixed” parallax_image_speed=”standard” bg_video_loop=”yes” parallax_video_height=”window-height” row_top_style=”none” row_bottom_style=”none” parallax_video_overlay=”none” row_overlay_opacity=”0″ remove_element_spacing=”no” row_col_spacing=”0″ row_col_pos=”default” row_col_equal_heights=”no” row_expanding=”no” row_animation=”none” row_animation_delay=”0″ minimize_row=”yes” simplified_controls=”yes” custom_css_percentage=”no” custom_css=”margin-top: 0px;margin-bottom: 0px;” border_styling_global=”default” width=”1\/1″ el_position=”first last”] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”1\/3″ el_position=”first”]\n

\"\"<\/p>\n[\/spb_text_block] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”2\/3″ el_position=”last”]\n

Schematic representation of MamoRef System.<\/span><\/h2>\n

Each pixel of each image is treated as an independent detector, thus there are thousands of source-detector pairs for each wavelength. Using a model of the most probable paths of light within the tissue, it is possible to infer which portion of the tissue affects each of these pairs and, for example, to be able to determine which areas of the breast have greater or lesser absorption of light in each one. wavelengths. Thus then, the images are processed with an algorithm that cleanses, and reconstructs a final image for clinical evaluation.<\/span><\/p>\n

Based on the functional premise that the propagation of different wavelengths of light in the NIR region depends on the type of tissue, it is possible to obtain a map of oxygenation and hemoglobin concentration, related to metabolic function.<\/span><\/p>\n[\/spb_text_block] [spb_blank_spacer height=”30px” responsive_vis=”hidden-xs” width=”1\/1″ el_position=”first last”] [\/spb_row] [spb_row element_name=”Row” wrap_type=”content-width” parallax_image_height=”content-height” parallax_image_movement=”fixed” parallax_image_speed=”0.5″ bg_video_loop=”yes” parallax_video_height=”window-height” parallax_video_overlay=”none” row_overlay_opacity=”0″ row_col_pos=”default” minimize_row=”yes” width=”1\/1″ el_position=”first last”] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”1\/2″ el_position=”first”]\n

MamoRef has the potential to help in the diagnosis of complementary evaluation and classification of injuries in a simple, efficient and non-invasive way, providing metabolic information associated with the type of injury.<\/span><\/strong><\/h2>\n

 <\/p>\n[\/spb_text_block] [spb_text_block animation=”none” animation_delay=”0″ simplified_controls=”yes” custom_css_percentage=”no” padding_vertical=”0″ padding_horizontal=”0″ margin_vertical=”0″ custom_css=”margin-top: 0px;margin-bottom: 0px;” border_size=”0″ border_styling_global=”default” width=”1\/2″ el_position=”last”]\n

These uses are based on the following hypotheses to be clinically validated:<\/span><\/h2>\n